She was graduated in the Stockholm Opera School in 1996. Shortly afterwards, she made her international debut performing the Second symphony by Mahler with the Berlin Philharmonic Orchestra and Claudio Abbado and the operatic debut in the role of Erda in Das Rheingold (The Gold of the Rhine), by Wagner, at the German Opera in Berlin and under the baton of Daniel Barenboim.
In concert, Anna Larsson has international fame as a virtuoso performer of the Gustav Mahler works. She often sings with the world's leading orchestras, such as the Berlin Philharmonic, the Lucerne Festival Orchestra, the New York Philharmonic, the Vienna Philharmonic, the Chicago Symphony Orchestra, and the London Symphony and Philharmonic Orchestras. She has sung with prestigious conductors such as Esa-Pekka Salonen, Daniel Harding, Sir Simon Rattle, Sir Antonio Pappano, Gustavo Dudamel, Alan Gilbert and Nikolaus Harnoncourt. In 2010 King Charles XVI Gustave of Sweden named her court singer and in 2011 she opened her own concert hall, Vattnäs Concert Bam.
Recent roles include Erda with Barenboim at the German Opera and also with Jurowski and the London Philharmonic Orchestra, Princess Zia of Sister Angelica at the Norwegian Opera and the Waltraute of Götterdämmerung (The sunset of the gods) at the MUPA in Budapest. She has also performed with Los Angeles Philharmonic and the conducting of Dudamel and the Singapore Symphony Orchestra.
She will be performing soon Das Lied von der Erde (The Song of the Earth) at the Ludwigsburg Festival, Peer Gynt with the Dresden Philharmonic and the directon of Storgårds, The dream of Gerontius under the baton of Marin Alsop in Sao Paulo and the Second symphony by Mahler with conductor Szeps-Znaider and the Lyon National Orchestra. Later, Larsson will return to the Malmö Opera with Dialogues des Carmélites (Dialogues of Carmelites) and Sister Angelica.